The research blog features scientific contributions made by study investigators and research collaborators highlighting findings from the PORCH and CHAP studies starting from 2019.

Social Engagement, Depressive Symptoms, and Loneliness, and Longitudinal Cognitive Decline in a Population-Based Cohort of Older Adults
Social engagement can slow cognitive decline even in individuals experiencing loneliness and/ or depressive symptoms.

APOE4, Blood Neurodegenerative Biomarkers, and Cognitive Decline in Community-Dwelling Older Adults
In this cohort study of 1038 community-dwelling older adults, higher levels of neurodegeneration (total tau), axonal injuries (neurofilament light), and reactive astrocytes and neuroinflammation (glial fibrillary acidic proteins) were associated with accelerated cognitive decline in genetically susceptible APOE4 carriers without dementia compared with noncarriers.

Longitudinal associations between lipid panel and cognitive decline modified by APOE 4 carrier status in biracial community-dwelling older adults: Findings from the Chicago health and aging project
We addressed previous limitations by investigating a comprehensive panel of lipids in a large longitudinal cohort to disentangle complex interactions and clarify the relationship among lipid species, APOE, and cognitive decline.

The Social Vulnerability Index and Incidence of Alzheimer Disease in a Population-Based Sample of Older Adults
The primary study objective was to examine the association between Social Vulnerability index (SVI) and risk of incident Alzheimer disease (AD) and rate of cognitive decline.

Cardiovascular Health and Biomarkers of Neurodegenerative Disease in Older Adults
In this cohort study of 1018 older adult participants (aged ≥65 years) in the Chicago Health and Aging Project, those with high CVH scores had significantly lower serum concentrations of neurofilament light chain, but CVH scores were not associated with total tau concentrations.